In vivo Antinociceptive Effect of Methanolic Extract of Ipomoea marginata Desr. in Rodents as well as In silico Molecular Docking of Some Phytoconstituents from the Plant

This research was performed to analyze the antinociceptive task of methanolic extract Ipomoea marginata in addition silico evaluation separated constituents from versus cyclooxygenase 2 enzyme together with absorption, distribution, metabolism, excretion/toxicity analysis substances. In vivo examined by acetic acid-induced agonizing, tail immersion and hot plate on rodents. activity isolated substances, assessment carried out Autodock 4.0 data warrior software applications. The results revealed that has greatest possible dose-dependent at all doses. Amongst Ipalbidine showed very best docking score -8.26, which virtually better than standard diclofenac, i.e., -7.03, guaranteeing good binding compatibility among ligand receptor using assures compound not breached Lipinski's guideline five suggesting its safety consumption. To conclude, can be a potent resource also additional simulation studies are needed develop performance Ipalbidine.